I am often asked this question by both patients and other healthcare providers and staff. Some patients insist that one or the other of these products is the only product that gives them results.

Let’s break down the differences. First, we must understand that Botox, Dysport, and Xeomin are each classified as a “neuromodulator” –  a tiny protein that interferes with the synaptic transmission in our nerve cells.

Botulinum toxin type A is the neuromodulator used in Botox, Dysport, and Xeomin. It disables certain endings and can make changes in the way the face hangs and folds, and the way you make expressions. Neuromodulators are also referred to as “neurotoxins.”

Botox, Dysport, and Xeomin are different brands, but what is important is their molecular makeup. Botox is considered a complex protein, while Dysport is a combo protein, and Xeomin strips the molecule of complex proteins to its purest injectable form.

All three have been scientifically compared and proven to work equally well. All studies have shown that one does not last longer than the other. They all last three to five months and can take two to five days to work, but the prices and the way they function definitely can differ.

Botox is made by Allergan and is officially marketed to temporarily improve the look of both moderate to severe crow’s feet and frown lines between the eyebrows. However, it is used off label for many other purposes. Results usually happen in six to 10 days, and the durations last usually three months for most of our patients.  

Botox has been around since the early-1990s. Dysport and Xeomin came into play in 2009 and 2011. Generally, more people know of Botox and usually feel more comfortable and confident with it. Botox is the most versatile, and you also can save with the Brilliant Distinction Program. Save those points, my friend! Adding up points up from CoolSculpting all the way up to Botox can save you lots of money in free rewards!

Dysport is made by Galderma and is marketed for the temporary improvement in the look of moderate to severe frown lines. Dysport, as well, has off-label uses. The results are usually visible within a few days, and the durations are at around 90 days. You can save cash with Galderma’s Aspire Reward Program.

Xeomin does not have to be refrigerated and has no additives, and it is no different than Botox and Dysport. Xeomin does have a rewards program called Xperience.

The most common targeted areas for neuromodulators are horizontal lines across the forehead and perpendicular frown lines between the lines (we call these your “elevens”). These treatments can help with crow’s feet, nasal squint lines – i.e. bunny lines, platysmal bands around the neck, eyebrow lifting, migraines, profuse underarm sweating, facial slimming, and relief for masseter muscle pain caused by teeth grinding.

The procedure usually takes around 15 to 20 minutes, and cost can range from $300 to $900, depending on the treatment area(s). You may experience some slight redness or swelling at the injection site, but only momentarily. You can resume your normal activities quickly. You may have a small bruise, but nothing a little concealer can’t hide.

In short, you’re in the South, and it’s much like Coke versus Pepsi when it comes to these three products. They are all neuromodulators. They are all going to alter the nerve impulse of targeted muscles and reduce or eliminate contracted or inducted wrinkles. The only difference is your particular taste. Personally, I prefer my Coke, thank you very much…